Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The combination of genetic instability and clonal expansion predicts progression to esophageal adenocarcinoma.

Cancer research - 15 Oct 2004

Maley Carlo C, Galipeau Patricia C, Li Xiaohong, Sanchez Carissa A, Paulson Thomas G, Blount Patricia L, Reid Brian J

Abstract excerpt

There is debate in the literature over the relative importance of genetic instability and clonal expansion during progression to cancer. Barrett's esophagus is a uniquely suited model to investigate neoplastic progression prospectively because periodic endoscopic biopsy surveillance is recommended for early detection of esophageal adenocarcinoma. We hypothesized that expansion of clones with genetic instability...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Aneuploidy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Barrett Esophagus

Share to Disease Progression

Share to Esophageal Neoplasms

Share to Genes, p16

Share to Genes, p53

Share to Loss of Heterozygosity

Source

Identifiers

PMID: 15492292
DOI: 10.1158/0008-5472.CAN-04-1738

Genes

CDKN2A
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The combination of genetic instability and clonal expansion predicts progression to esophageal adenocarcinoma.PMID 15492292Read ↗

Assessment of Esophageal Adenocarcinoma Risk Using Somatic Chromosome Alterations in Longitudinal Samples in Barrett's Esophagus.Semantic proximity Read ↗

A comprehensive survey of clonal diversity measures in Barrett's esophagus as biomarkers of progression to esophageal adenocarcinoma.Semantic proximity Read ↗

Evolution of neoplastic cell lineages in Barrett oesophagus.Semantic proximity Read ↗

p16(INK4a) lesions are common, early abnormalities that undergo clonal expansion in Barrett's metaplastic epithelium.Semantic proximity Read ↗

Genetic clonal diversity predicts progression to esophageal adenocarcinomaSemantic proximity Read ↗

Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett's oesophagus.Semantic proximity Read ↗

Dynamic clonal equilibrium and predetermined cancer risk in Barrett's oesophagus.Semantic proximity Read ↗

New strategies in Barrett's esophagus: integrating clonal evolutionary theory with clinical management.Semantic proximity Read ↗

Temporal and spatial evolution of somatic chromosomal alterations: a case-cohort study of Barrett's esophagus.Semantic proximity Read ↗

The Presence of Genetic Mutations at Key Loci Predicts Progression to Esophageal Adenocarcinoma in Barrett's Esophagus.Semantic proximity Read ↗

Genetic Mechanisms of TP53 Loss of Heterozygosity in Barrett's Esophagus: Implications for Biomarker ValidationSemantic proximity Read ↗

Evolution of Esophageal Adenocarcinoma From Precursor Lesion Stem Cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.