p16(INK4a) lesions are common, early abnormalities that undergo clonal expansion in Barrett's metaplastic epithelium.

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Article

p16(INK4a) lesions are common, early abnormalities that undergo clonal expansion in Barrett's metaplastic epithelium.

Cancer research - 15 Nov 2001

Wong D J, Paulson T G, Prevo L J, Galipeau P C, Longton G, Blount P L, Reid B J

Abstract excerpt

Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma, a cancer of which the incidence has been increasing at an alarming rate in Western countries. p16(INK4a) lesions occur frequently in esophageal adenocarcinomas but their role in neoplastic progression is not well understood. We detected 9p21 loss of heterozygosity, p16 CpG island methylation, and p16 mutations in biopsies from 57%,...

Topics

Adult
Aged
Aged, 80 and over
Aneuploidy
Barrett Esophagus
Biopsy
Chromosomes, Human, Pair 9
Clone Cells
CpG Islands
Cyclin-Dependent Kinase Inhibitor p16
DNA Methylation
Epithelial Cells
Esophageal Neoplasms
Humans

Source

Open in PubMed

Identifiers

PMID: 11719461

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Loss of Heterozygosity

Metaphase

Middle Aged

Mutation