Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic pathways in the evolution of morphologically distinct colorectal neoplasms.

Cancer research - 15 Mar 2001

Yashiro M, Carethers J M, Laghi L, Saito K, Slezak P, Jaramillo E, Rubio C, Koizumi K, Hirakawa K, Boland C R

Abstract excerpt

Colorectal adenomas can be morphologically classified as exophytic or flat. Polypoid cancers and cancers arising de novo (ie., without any adenomatous component) might be the results of genetic progression from exophytic and flat adenomas, respectively. In this study, we examined 94 morphologically distinct neoplastic specimens for mutations in K-RAS and analyzed 10 microsatellite loci tightly linked to the tumor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Colorectal Neoplasms
Share to Genes, ras

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Intestinal Polyps

Share to Loss of Heterozygosity

Share to Microsatellite Repeats

Share to Polyploidy

Source

Identifiers

PMID: 11289147

Genes

APC
DCC
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic pathways in the evolution of morphologically distinct colorectal neoplasms.PMID 11289147Read ↗

Evolution of colorectal cancer: change of pace and change of direction.Semantic proximity Read ↗

Different genetic features associated with colon and rectal carcinogenesis.Semantic proximity Read ↗

RAS, Cellular Plasticity, and Tumor Budding in Colorectal CancerSemantic proximity Read ↗

Multiclonal colorectal cancers with divergent histomorphological features and RAS mutations: one cancer or separate cancers?Semantic proximity Read ↗

Epithelial and stromal genetic instability contributes to genesis of colorectal adenomasSemantic proximity Read ↗

Refining molecular analysis in the pathways of colorectal carcinogenesis.Semantic proximity Read ↗

Tracing cell fates in human colorectal tumors from somatic microsatellite mutations: evidence of adenomas with stem cell architecture.Semantic proximity Read ↗

Genetic epidemiology of mutated K-ras proto-oncogene, altered suppressor genes, and microsatellite instability in colorectal adenomas.Semantic proximity Read ↗

Somatically acquired genetic alterations in flat colorectal neoplasias.Semantic proximity Read ↗

Distribution of genetic variants in preneoplastic areas of colorectal tumours.Semantic proximity Read ↗

Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance.Semantic proximity Read ↗

K-ras codon 12 mutation determines the polypoid growth of colorectral cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.