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Article

Genomic landscape of allelic imbalance in premalignant atypical adenomatous hyperplasias of the lung

21 Mar 2019

Abstract excerpt

BACKGROUND: Genomic investigation of atypical adenomatous hyperplasia (AAH), the only known precursor lesion to lung adenocarcinomas (LUAD), presents challenges due to the low mutant cell fractions. This necessitates sensitive methods for detection of chromosomal aberrations to better study the role of critical alterations in early lung cancer pathogenesis and the progression from AAH to LUAD. METHODS: We applied...

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Share to Genomic variations and chromosomal abnormalities
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PMID: 30905849
DOI: 10.1016/j.ebiom.2019.03.020

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