Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dependence of the Cytotoxicity of DNA-Damaging Agents on the Mismatch Repair Status of Human Cells

15 May 2004

Abstract excerpt

Mismatch repair (MMR) deficiency was reported to increase resistance of mammalian cells to killing by several genotoxic substances. However, although MMR-deficient cells are approximately 100-fold more resistant to killing by S(N)1 type methylating agents than MMR-proficient controls, the sensitivity differences reported for the other agents were typically <2-fold. To test whether these differences were linked to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to DNA Repair Mechanisms
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15150090
DOI: 10.1158/0008-5472.can-04-0513

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dependence of the Cytotoxicity of DNA-Damaging Agents on the Mismatch Repair Status of Human CellsPMID 15150090Read ↗

Mismatch repair defects as a cause of resistance to cytotoxic drugs.Semantic proximity Read ↗

Mismatch repair and response to DNA-damaging antitumour therapies.Semantic proximity Read ↗

Role of Mismatch Repair and MGMT in Response to Anticancer TherapiesSemantic proximity Read ↗

Drug-induced DNA damage and tumor chemosensitivity.Semantic proximity Read ↗

Cellular resistance and hypermutability in mismatch repair-deficient human cancer cell lines following treatment with methyl methanesulfonate.Semantic proximity Read ↗

Acceleration of lymphomagenesis in mismatch-repair deficient mice by exposure to genotoxic agents.Semantic proximity Read ↗

Specificity of mutations induced by methyl methanesulfonate in mismatch repair-deficient human cancer cell lines.Semantic proximity Read ↗

Mismatch Repair Status and the Response of Human Cells to CisplatinSemantic proximity Read ↗

Signalling cell cycle arrest and cell death through the MMR SystemSemantic proximity Read ↗

Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine.Semantic proximity Read ↗

Decreased UV sensitivity, mismatch repair activity and abnormal cell cycle checkpoints in skin cancer cell lines derived from UVB-irradiated XPA-deficient mice.Semantic proximity Read ↗

Resistance to 6-thioguanine in mismatch repair-deficient human cancer cell lines correlates with an increase in induced mutations at the HPRT locus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.