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Article

Signalling cell cycle arrest and cell death through the MMR System

6 Dec 2005

Abstract excerpt

Loss of DNA mismatch repair (MMR) in mammalian cells, as well as having a causative role in cancer, has been linked to resistance to certain DNA damaging agents including clinically important cytotoxic chemotherapeutics. MMR-deficient cells exhibit defects in G2/M cell cycle arrest and cell killing when treated with these agents. MMR-dependent cell cycle arrest occurs, at least for low doses of alkylating agents,...

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PMID: 16332722
DOI: 10.1093/carcin/bgi298

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Source receipt: pubmed, retrieved 7 Sept 2026.

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