Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acceleration of lymphomagenesis in mismatch-repair deficient mice by exposure to genotoxic agents.

Toxicology letters - 15 Mar 2000

Jansen L, Claij N, Dekker M, van Klink Y, van der Valk M, van 't Wout K, te Riele H

Abstract excerpt

Hemizygosity for genes that are essential for DNA mismatch repair (MMR) was found to underlie cancer predisposition in hereditary nonpolypsis colorectal cancer (HNPCC). Loss of the wild-type allele generates a MMR-deficient cell compartment with a high propensity to oncogenic transformation. MMR deficiency not only accelerates spontaneous mutagenesis resulting from DNA replication errors, but also affects the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Pair Mismatch
Share to Cells, Cultured
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Lymphoma

Share to Mutagens

Share to MutS Homolog 2 Protein

Share to Proto-Oncogene Proteins

Source

Identifiers

PMID: 10720738
DOI: 10.1016/s0378-4274(99)00277-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acceleration of lymphomagenesis in mismatch-repair deficient mice by exposure to genotoxic agents.PMID 10720738Read ↗

DNA mismatch repair: molecular mechanism, cancer, and ageing.Semantic proximity Read ↗

Mutations in DNA mismatch repair genes: implications for DNA damage signaling and drug sensitivity (review).Semantic proximity Read ↗

Functional consequences of DNA mismatch repair missense mutations in murine models and their impact on cancer predisposition.Semantic proximity Read ↗

DNA mismatch repair-dependent DNA damage responses and cancerSemantic proximity Read ↗

Mismatch repair defects in human carcinogenesis.Semantic proximity Read ↗

Molecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesis.Semantic proximity Read ↗

Mammalian DNA Mismatch RepairSemantic proximity Read ↗

DNA mismatch repair deficiency stimulates N-ethyl-N-nitrosourea-induced mutagenesis and lymphomagenesis.Semantic proximity Read ↗

DNA mismatch repair in mammals: role in disease and meiosis.Semantic proximity Read ↗

Geminin ablation in vivo enhances tumorigenesis through increased genomic instability.Semantic proximity Read ↗

Mouse models of DNA mismatch repair in cancer research.Semantic proximity Read ↗

Mice defective in the DNA mismatch gene PMS2 are hypersensitive to MNU induced thymic lymphoma and are partially protected by transgenic expression of human MGMT.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.