Article
Decreased UV sensitivity, mismatch repair activity and abnormal cell cycle checkpoints in skin cancer cell lines derived from UVB-irradiated XPA-deficient mice.
Mutation research - 31 May 2000
Ichikawa M, Nakane H, Marra G, Corti C, Jiricny J, Fitch M, Ford J M, Ikejima M, Shimada T, Yoshino M, Takeuchi S, Nakatsu Y, Tanaka K
Abstract excerpt
Xeroderma pigmentosum group A gene (XPA)-deficient mice are defective in nucleotide excision repair (NER) and are therefore highly sensitive to ultraviolet (UV)-induced skin carcinogenesis. We established cell lines from skin cancers of UVB-irradiated XPA-deficient mice to investigate the phenotypic changes occurring during skin carcinogenesis. As anticipated, the skin cancer cell lines were devoid of NER...
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