Article
Mismatch repair defects as a cause of resistance to cytotoxic drugs.
Expert review of anticancer therapy - 1 Jun 2001
Irving J A, Hall A G
Abstract excerpt
In this short review, we aim to bring together the most recent evidence implicating mismatch repair pathway defects as a cause of drug resistance to a spectrum of chemotherapeutic agents in a variety of cancers. Experimental and clinical studies are discussed and possible strategies that may be employed to overcome the multidrug resistant phenotype afforded by such defects.
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