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Article

Role of Mismatch Repair and MGMT in Response to Anticancer Therapies

1 May 2008

Abstract excerpt

Tumor resistance to cytotoxic chemotherapy drugs and their toxicity to normal cells are major clinical obstacles to anticancer therapy effectiveness. Alterations in various DNA repair pathways play a key role in the development of both mechanisms of drug resistance and toxicity. Since deregulation of the DNA damage response and alterations in DNA repair pathways are relatively common in human cancer, the...

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PMID: 18473722
DOI: 10.2174/187152008784220276

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