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Article

Resistance to 6-thioguanine in mismatch repair-deficient human cancer cell lines correlates with an increase in induced mutations at the HPRT locus.

Carcinogenesis - 1 Nov 1998

Glaab W E, Risinger J I, Umar A, Barrett J C, Kunkel T A, Tindall K R

Abstract excerpt

Although the resistance to the cytotoxic response of certain DNA damaging agents has been well characterized in cells deficient in mismatch repair, little is known about how such resistance affects mutagenesis. Using human cancer cell lines defective in mismatch repair (MMR) and complementary cell lines in which the MMR defects were corrected by chromosome transfer, we present the cytotoxic effect and the...

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PMID: 9855005
DOI: 10.1093/carcin/19.11.1931

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