Article
Resistance to 6-thioguanine in mismatch repair-deficient human cancer cell lines correlates with an increase in induced mutations at the HPRT locus.
Carcinogenesis - 1 Nov 1998
Glaab W E, Risinger J I, Umar A, Barrett J C, Kunkel T A, Tindall K R
Abstract excerpt
Although the resistance to the cytotoxic response of certain DNA damaging agents has been well characterized in cells deficient in mismatch repair, little is known about how such resistance affects mutagenesis. Using human cancer cell lines defective in mismatch repair (MMR) and complementary cel...
Topics
- Adaptor Proteins, Signal Transducing
- Antimetabolites, Antineoplastic
- Carrier Proteins
- Cell Survival
- Chromosome Mapping
- DNA Repair
- DNA-Binding Proteins
- Drug Resistance, Neoplasm
- Fungal Proteins
- Humans
- Hypoxanthine Phosphoribosyltransferase
- MutL Protein Homolog 1
- Mutation
- Neoplasm Proteins
- Nuclear Proteins
- Saccharomyces cerevisiae Proteins
- Thioguanine
- Tumor Cells, Cultured