Cellular resistance and hypermutability in mismatch repair-deficient human cancer cell lines following treatment with methyl methanesulfonate.

doi:10.1016/s0027-5107(98)00004-9

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Article

Cellular resistance and hypermutability in mismatch repair-deficient human cancer cell lines following treatment with methyl methanesulfonate.

Mutation research - 26 Feb 1998

Glaab W E, Risinger J I, Umar A, Barrett J C, Kunkel T A, Tindall K R

Abstract excerpt

Resistance to the cytotoxic effects of S(N)1 alkylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and N-methyl-N-nitrosourea (MNU) is well established in mismatch repair-defective cells, however, little is known about the cellular response to S(N)2 alkylating agents in these cell...

Topics

Cell Line
DNA Repair
Humans
Methyl Methanesulfonate
Mutagens
Mutation
Nucleic Acid Heteroduplexes
Tumor Cells, Cultured

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