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Article

Mismatch Repair Status and the Response of Human Cells to Cisplatin

15 Jul 2007

Abstract excerpt

The emergence of resistance to cisplatin is a serious drawback of cancer therapy. To help elucidate the molecular basis of this resistance, we examined matched ovarian cancer cell lines that differ in their DNA mismatch repair (MMR) status and the response to cisplatin. Checkpoint activation by cisplatin was identical in both lines. However, sensitive cells delayed S-phase transition, arrested at G(2)/M and died...

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PMID: 17622800
DOI: 10.4161/cc.6.14.4472

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