Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drug-induced DNA damage and tumor chemosensitivity.

1 Dec 1990

Abstract excerpt

Cytotoxic drugs act principally by damaging tumor-cell DNA. Quantitative analysis of this interaction provides a basis for understanding the biology of therapeutic cell kill as well as a rational strategy for optimizing and predicting tumor response. Recent advances have made it possible to correlate assayed DNA lesions with cytotoxicity in tumor cell lines, in animal models, and in patients with malignant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cancer therapeutics and mechanisms
Share to Cancer Treatment and Pharmacology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 2230898
DOI: 10.1200/jco.1990.8.12.2062

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drug-induced DNA damage and tumor chemosensitivity.PMID 2230898Read ↗

Targeting DNA damage response pathways in tumor drug resistance: Mechanisms, clinical implications, and future directionsSemantic proximity Read ↗

Exploiting DNA repair pathways for tumor sensitization, mitigation of resistance, and normal tissue protection in radiotherapySemantic proximity Read ↗

DNA damage response inhibitors in cancer therapy: Mechanisms, clinical development, and combination strategiesSemantic proximity Read ↗

DNA Damage and Repair in Human Cancer: Molecular Mechanisms and Contribution to Therapy-Related LeukemiasSemantic proximity Read ↗

DNA repair and the contribution to chemotherapy resistanceSemantic proximity Read ↗

DNA Adducts in Cancer ChemotherapySemantic proximity Read ↗

DNA Damage Response Assessments in Human Tumor Samples Provide Functional Biomarkers of RadiosensitivitySemantic proximity Read ↗

DNA damage caused by chemotherapy has duality, and traditional Chinese medicine may be a better choice to reduce its toxicitySemantic proximity Read ↗

Coordination of DNA Mismatch Repair and Base Excision Repair Processing of Chemotherapy and Radiation Damage for Targeting Resistant CancersSemantic proximity Read ↗

Human mismatch repair, drug-induced DNA damage, and secondary cancerSemantic proximity Read ↗

Epigenetic targeting of DNA damage response (DDR)-related mechanisms to overcome acquired cisplatin resistance of tumor cellsSemantic proximity Read ↗

Molecular Pathways: Overcoming Radiation Resistance by Targeting DNA Damage Response PathwaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.