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Article

Cooperative methylation of human tRNA3Lys at positions A58 and U54 drives the early and late steps of HIV-1 replication.

Nucleic acids research - 18 Nov 2021

Fukuda Hiroyuki, Chujo Takeshi, Wei Fan-Yan, Shi Sheng-Lan, Hirayama Mayumi, Kaitsuka Taku, Yamamoto Takahiro, Oshiumi Hiroyuki, Tomizawa Kazuhito

Abstract excerpt

Retroviral infection requires reverse transcription, and the reverse transcriptase (RT) uses cellular tRNA as its primer. In humans, the TRMT6-TRMT61A methyltransferase complex incorporates N1-methyladenosine modification at tRNA position 58 (m1A58); however, the role of m1A58 as an RT-stop site during retroviral infection has remained questionable. Here, we constructed TRMT6 mutant cells to determine the roles...

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Identifiers

PMID: 34642752
DOI: 10.1093/nar/gkab879
PMCID: PMC8599865

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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