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Article

Novel methyltransferase for modified uridine residues at the wobble position of tRNA.

Molecular and cellular biology - 1 Dec 2003

Kalhor Hamid R, Clarke Steven

Abstract excerpt

We have identified a novel tRNA methyltransferase in Saccharomyces cerevisiae that we designate Trm9. This enzyme, the product of the YML014w gene, catalyzes the esterification of modified uridine nucleotides, resulting in the formation of 5-methylcarbonylmethyluridine in tRNA(Arg3) and 5-methylcarbonylmethyl-2-thiouridine in tRNA(Glu). In intact yeast cells, disruption of the TRM9 gene results in the complete...

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Identifiers

PMID: 14645538
DOI: 10.1128/MCB.23.24.9283-9292.2003
PMCID: PMC309612

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