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Article

Dual function of the tRNA(m(5)U54)methyltransferase in tRNA maturation.

RNA (New York, N.Y.) - 1 Mar 2002

Johansson Marcus J O, Byström Anders S

Abstract excerpt

A 5-methyluridine (m(5)U) residue at position 54 is a conserved feature of bacterial and eukaryotic tRNAs. The methylation of U54 is catalyzed by the tRNA(m5U54)methyltransferase, which in Saccharomyces cerevisiae is encoded by the nonessential TRM2 gene. In this study, we identified four different strains with mutant forms of tRNA(Ser)CGA. The absence of the TRM2 gene in these strains decreased the stability of...

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Source

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Identifiers

PMID: 12003492
DOI: 10.1017/s1355838202027851
PMCID: PMC1370254

Genes

CGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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