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Article

Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA.

RNA (New York, N.Y.) - 1 Oct 2002

Alexandrov Andrei, Martzen Mark R, Phizicky Eric M

Abstract excerpt

7-methylguanosine (m7G) modification of tRNA occurs widely in eukaryotes and bacteria, is nearly always found at position 46, and is one of the few modifications that confers a positive charge to the base. Screening of a Saccharomyces cerevisiae genomic library of purified GST-ORF fusion proteins reveals two previously uncharacterized proteins that copurify with m7G methyltransferase activity on pre-tRNA(Phe)....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12403464
DOI: 10.1017/s1355838202024019
PMCID: PMC1370335

Genes

METTL1
WDR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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