Article
Genetic interaction between Wnt7a and Lrp6 during patterning of dorsal and posterior structures of the mouse limb.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jun 2005
Adamska Maja, Billi Allison C, Cheek Susannah, Meisler Miriam H
Abstract excerpt
Wnt7a and the Wnt coreceptor Lrp6 are both required for development of posterior digits and dorsal structures of the limb. We report that Lrp6 null mice lack Lmx1b expression in the distal mesenchyme, as previously described for Wnt7a mutants. The loss of Lmx1b expression in Wnt7a-/-Lrp6+/- double mutants did not differ from that in Wnt7a-/- mice. These data suggest that Wnt7a acts through Lrp6 to regulate Lmx1b...
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