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Article

Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina

3 Feb 2021

Abstract excerpt

Dysregulation of Wnt signaling is implicated in multiple ocular disorders. The roles of Wnt co-receptors LRP5 and LRP6 in Wnt signaling regulation remain elusive, as most retinal cells express both of the co-receptors. To address this question, LRP5 and LRP6 were individually knocked-out in a human retinal pigment epithelium cell line using the CRISPR-Cas9 technology. Wnt signaling activity induced by various Wnt...

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PMID: 33545636
DOI: 10.1016/j.bbrc.2021.01.068

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