Article
Novel Mutation of LRP6 Identified in Chinese Han Population Links Canonical WNT Signaling to Neural Tube Defects.
Birth defects research - 15 Jan 2018
Shi Zhiwen, Yang Xueyan, Li Bin-Bin, Chen Shuxia, Yang Luming, Cheng Liangping, Zhang Ting, Wang Hongyan, Zheng Yufang
Abstract excerpt
BACKGROUND: Neural tube defects (NTDs), the second most frequent cause of human congenital abnormalities, are debilitating birth defects due to failure of neural tube closure. It has been shown that noncanonical WNT/planar cell polarity (PCP) signaling is required for convergent extension (CE), the initiation step of neural tube closure (NTC). But the effect of canonical WNT//β-catenin signaling during NTC is...
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