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Article

Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 2004

Holmen Sheri L, Giambernardi Troy A, Zylstra Cassandra R, Buckner-Berghuis Bree D, Resau James H, Hess J Fred, Glatt Vaida, Bouxsein Mary L, Ai Minrong, Warman Matthew L, Williams Bart O

Abstract excerpt

UNLABELLED: Humans and mice lacking Lrp5 have low BMD. To evaluate whether Lrp5 and Lrp6 interact genetically to control bone or skeletal development, we created mice carrying mutations in both Lrp5 and the related gene Lrp6. We found that compound mutants had dose-dependent deficits in BMD and l...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Limb Deformities, Congenital

Share to Low Density Lipoprotein Receptor-Related Protein-5

Share to Low Density Lipoprotein Receptor-Related Protein-6

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Source

Identifiers

PMID: 15537447
DOI: 10.1359/JBMR.040907

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15537447-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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