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Article

Cloning and expression of Xenopus Lrp5 and Lrp6 genes.

Mechanisms of development - 1 Sept 2002

Houston Douglas W, Wylie Chris

Abstract excerpt

LRP5 and LRP6 comprise a subfamily of lipoprotein-receptor related proteins that function as co-receptors for Wnt proteins. Mutation of human LRP5 is responsible for osteoporosis-pseudoglioma syndrome and disruption of Lrp6 in mice causes similar effects to mutation of several different Wnt genes. We have cloned Xenopus homologues of Lrp5 and Lrp6 (Xlrp5, Xlrp6) and examined their expression during embryogenesis....

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Source

Identifiers

PMID: 12204281
DOI: 10.1016/s0925-4773(02)00205-8

Genes

LRP5
LRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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