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Article

Novel mutations in Lrp6 orthologs in mouse and human neural tube defects affect a highly dosage-sensitive Wnt non-canonical planar cell polarity pathway.

Human molecular genetics - 1 Apr 2014

Allache Redouane, Lachance Stéphanie, Guyot Marie Claude, De Marco Patrizia, Merello Elisa, Justice Monica J, Capra Valeria, Kibar Zoha

Abstract excerpt

Wnt signaling has been classified as canonical Wnt/β-catenin-dependent or non-canonical planar cell polarity (PCP) pathway. Misregulation of either pathway is linked mainly to cancer or neural tube defects (NTDs), respectively. Both pathways seem to antagonize each other, and recent studies have implicated a number of molecular switches that activate one pathway while simultaneously inhibiting the other thereby...

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Source

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Identifiers

PMID: 24203697
DOI: 10.1093/hmg/ddt558
PMCID: PMC3943515

Genes

LRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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