Article
Delayed dopaminergic neuron differentiation in Lrp6 mutant mice.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jan 2010
Castelo-Branco Gonçalo, Andersson Emma R, Minina Eleonora, Sousa Kyle M, Ribeiro Diogo, Kokubu Chikara, Imai Kenji, Prakash Nilima, Wurst Wolfgang, Arenas Ernest
Abstract excerpt
Wnts are known to bind and activate multiple membrane receptors/coreceptors and to regulate dopaminergic (DA) neuron development and ventral midbrain (VM) morphogenesis. The low density lipoprotein receptor-related protein (Lrp6) is a Wnt co-receptor, yet it remains unclear whether Lrp6 is required for DA neuron development or VM morphogenesis. Lrp6 is expressed ubiquitously in the developing VM. In this study,...
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