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Article

An IgE-associated polymorphism in STAT6 alters NF-kappaB binding, STAT6 promoter activity, and mRNA expression.

The Journal of allergy and clinical immunology - 1 Sept 2009

Schedel Michaela, Frei Remo, Bieli Christian, Cameron Lisa, Adamski Jerzy, Lauener Roger, Kabesch Michael

Abstract excerpt

BACKGROUND: The IL-4/IL-13 pathway is central for IgE regulation. Signal transducer and activator of transcription 6 (STAT6) is the major transcription factor within this pathway. STAT6 polymorphisms were recently associated with elevated total IgE levels in a genome-wide association study. OBJECTIVE: This study aimed to assess biological mechanisms by which an IgE-associated genetic variation in STAT6 may...

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Source

Identifiers

PMID: 19665768
DOI: 10.1016/j.jaci.2009.06.024

Genes

STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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An IgE-associated polymorphism in STAT6 alters NF-kappaB binding, STAT6 promoter activity, and mRNA expression.PMID 19665768Read ↗

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