Prevalence, distribution and functional significance of the -237C to T polymorphism in the IL-12Rβ2 promoter in Indian tuberculosis patients.

doi:10.1371/journal.pone.0034355

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Article

Prevalence, distribution and functional significance of the -237C to T polymorphism in the IL-12Rβ2 promoter in Indian tuberculosis patients.

PloS one - 1 Jan 2012

Verma Vikas Kumar, Taneja Vibha, Jaiswal Anand, Sharma Sangeeta, Behera Digamber, Sreenivas Vishnubhatla, Chauhan Shyam Singh, Prasad Hanumanthappa Krishna

Abstract excerpt

Cytokine/cytokine receptor gene polymorphisms related to structure/expression could impact immune response. Hence, the -237 polymorphic site in the 5' promoter region of the IL-12Rβ2 (SNP ID: rs11810249) gene associated with the AP-4 transcription motif GAGCTG, was examined. Amplicons encompassing the polymorphism were generated from 46 pulmonary tuberculosis patients, 35 family contacts and 28 miscellaneous...

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PMID: 22509293
DOI: 10.1371/journal.pone.0034355
PMCID: PMC3317943

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