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Article

Association of the IL12RB1 promoter polymorphisms with increased risk of atopic dermatitis and other allergic phenotypes.

Human molecular genetics - 1 Nov 2005

Takahashi Naomi, Akahoshi Mitsuteru, Matsuda Akira, Ebe Kouji, Inomata Naoko, Obara Kazuhiko, Hirota Tomomitsu, Nakashima Kazuko, Shimizu Makiko, Tamari Mayumi, Doi Satoru, Miyatake Akihiko, Enomoto Tadao, Nakashima Hitoshi, Ikezawa Zenro, Shirakawa Taro

Abstract excerpt

Atopic dermatitis (AD) is frequently associated with eosinophilia, highly elevated immunoglobulin E (IgE) levels and increased levels of T-helper 2-type (Th2) cytokines in skin lesions due to infiltrating T cells. Interleukin-12 (IL-12), in combination with interferon-gamma (IFN-gamma), inhibits IgE synthesis and Th2 cell function. As the IFN-gamma-inducing cytokines IL-12 and IL-23 utilize IL-12Rbeta1 as part of...

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PMID: 16159888
DOI: 10.1093/hmg/ddi347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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