Article
The 5,10-methylenetetrahydrofolate reductase C677T polymorphism interacts with smoking to increase homocysteine.
Atherosclerosis - 1 Jun 2004
Brown Karen S, Kluijtmans Leo A J, Young Ian S, Murray Liam, McMaster Dorothy, Woodside Jayne V, Yarnell John W G, Boreham Colin A, McNulty Helene, Strain J J, McPartlin Joseph, Scott John M, Mitchell Laura E, Whitehead Alexander S
Abstract excerpt
Elevated homocysteine is a risk marker for several human pathologies. Risk factors for elevated homocysteine include low folate and homozygosity for the T allele of the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism. Because nitric oxide may inhibit folate catabolism and endothelial nitric oxide synthase activity is reduced in smokers, we postulated that smoking status might modify the impact...
Topics
- Adult
- Cohort Studies
- Female
- Folic Acid
- Genetic Predisposition to Disease
- Genotype
- Humans
- Hyperhomocysteinemia
- Linear Models
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Polymorphism, Genetic