Article
A common polymorphism in the methylenetetrahydrofolate reductase gene, homocysteine, and ischemic cerebrovascular disease.
Stroke - 1 Sept 1997
Markus H S, Ali N, Swaminathan R, Sankaralingam A, Molloy J, Powell J
Abstract excerpt
BACKGROUND AND PURPOSE: A common polymorphism (T/t) in the gene encoding the methylenetetrahydrofolate reductase (MTHFR) enzyme has been associated with elevated serum homocysteine, itself a risk factor for stroke. Some studies have reported an association with ischemic heart disease, but no publ...
Topics
- Aged
- Brain Ischemia
- Female
- Folic Acid
- Gene Frequency
- Genotype
- Homocysteine
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Osmolar Concentration
- Oxidoreductases Acting on CH-NH Group Donors
- Polymorphism, Genetic
- Reference Values