Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methylenetetrahydrofolate reductase (MTHFR) c677t gene variant modulates the homocysteine folate correlation in a mild folate-deficient population.

Clinica chimica acta; international journal of clinical chemistry - 1 Feb 2004

Pereira Alexandre C, Schettert Isolmar Tadeu, Morandini Filho Antônio Alberto F, Guerra-Shinohara Elvira Maria, Krieger José E

Abstract excerpt

BACKGROUND: A large body of evidence links plasma concentrations of homocysteine and cardiovascular disease. Several genetic and environmental variables may modulate such relationship. We investigated the influence of methylenetetrahydrofolate reductase (MTHFR) gene variants C677T, A1298C, and T1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Folic Acid
Share to Folic Acid Deficiency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MTHFR gene

Share to Genotype

Share to Homocysteine

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Genetic

Share to Vitamin B 12

Source

Identifiers

PMID: 14734201
DOI: 10.1016/j.cccn.2003.09.016

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14734201-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methylenetetrahydrofolate reductase (MTHFR) c677t gene variant modulates the homocysteine folate correlation in a mild folate-deficient population.PMID 14734201Read ↗

The methylenetetrahydrofolate reductase 677C->T polymorphism and dietary folate restriction affect plasma one-carbon metabolites and red blood cell folate concentrations and distribution in women.Semantic proximity Read ↗

Prevalence and effects of gene-gene and gene-nutrient interactions on serum folate and serum total homocysteine concentrations in the United States: findings from the third National Health and Nutrition Examination Survey DNA Bank.Semantic proximity Read ↗

The 5,10-methylenetetrahydrofolate reductase C677T polymorphism interacts with smoking to increase homocysteine.Semantic proximity Read ↗

Genetic polymorphisms and folate status.Semantic proximity Read ↗

The methylenetetrahydrofolate reductase 677C-->T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism.Semantic proximity Read ↗

A common polymorphism in the methylenetetrahydrofolate reductase gene, homocysteine, and ischemic cerebrovascular disease.Semantic proximity Read ↗

Biological and clinical implications of the MTHFR C677T polymorphism.Semantic proximity Read ↗

Alcohol intake and methylenetetrahydrofolate reductase polymorphism modify the relation of folate intake to plasma homocysteine.Semantic proximity Read ↗

Homocysteine Metabolism Gene Polymorphisms (MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) Jointly Elevate the Risk of Folate Deficiency.Semantic proximity Read ↗

Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine and other risk factors for vascular disease.Semantic proximity Read ↗

Effect of the methylenetetrahydrofolate reductase 677C-->T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample.Semantic proximity Read ↗

The impact of MTHFR 677 C/T genotypes on folate status markers: a meta-analysis of folic acid intervention studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.