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Article

Genetic evidence that nitric oxide modulates homocysteine: the NOS3 894TT genotype is a risk factor for hyperhomocystenemia.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2003

Brown Karen S, Kluijtmans Leo A J, Young Ian S, Woodside Jayne, Yarnell John W G, McMaster Dorothy, Murray Liam, Evans Alun E, Boreham Colin A, McNulty Helene, Strain J J, Mitchell Laura E, Whitehead Alexander S

Abstract excerpt

OBJECTIVE: Mild hyperhomocystenemia is an independent, graded risk factor for cardiovascular disease. Genetic determinants of hyperhomocystenemia include functional polymorphisms in several folate/homocysteine metabolic enzymes. Nitric oxide may also modulate plasma homocysteine (tHcy) concentrations, either by direct inhibition of methionine synthase or via an indirect effect on folate catabolism. METHODS AND...

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Identifiers

PMID: 12689917
DOI: 10.1161/01.ATV.0000071348.70527.F4

Genes

NOS3
MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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