Article
Alcohol intake and methylenetetrahydrofolate reductase polymorphism modify the relation of folate intake to plasma homocysteine.
The American journal of clinical nutrition - 1 Jul 2005
Chiuve Stephanie E, Giovannucci Edward L, Hankinson Susan E, Hunter David J, Stampfer Meir J, Willett Walter C, Rimm Eric B
Abstract excerpt
BACKGROUND: Folate intake increases plasma folate and reduces total homocysteine (tHcy) concentrations, which may lower coronary artery disease (CAD) and cancer risks. Folate metabolism may be altered by alcohol intake and 2 common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C-->T and 1298A-->C. OBJECTIVE: We examined whether the associations between folate intake and plasma folate...
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