Cloned mouse N-acetyltransferases: enzymatic properties of expressed Nat-1 and Nat-2 gene products.

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Article

Cloned mouse N-acetyltransferases: enzymatic properties of expressed Nat-1 and Nat-2 gene products.

Molecular pharmacology - 1 Aug 1992

Martell K J, Levy G N, Weber W W

Abstract excerpt

N-Acetylation plays an important role in the metabolism of a wide variety of hydrazine drugs and arylamine drugs and carcinogens. Humans have genetically determined differences in their N-acetyltransferase activities and are phenotypically classified as rapid or slow acetylators. Mice have a similar genetic polymorphism in N-acetyltransferase activity and have been used as models of the human polymorphism in many...

Topics

Acetyltransferases
Animals
Blotting, Northern
Chlorocebus aethiops
Cloning, Molecular
Cytosol
Enzyme Stability
Gene Expression
Hot Temperature
Introns
Kidney
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver

Mice

Mice, Inbred A

Mice, Inbred Strains

Phenotype

Protein Biosynthesis

Source

Open in PubMed

Identifiers

PMID: 1513324

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1513324-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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