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Article

Cloned mouse N-acetyltransferases: enzymatic properties of expressed Nat-1 and Nat-2 gene products.

Molecular pharmacology - 1 Aug 1992

Martell K J, Levy G N, Weber W W

Abstract excerpt

N-Acetylation plays an important role in the metabolism of a wide variety of hydrazine drugs and arylamine drugs and carcinogens. Humans have genetically determined differences in their N-acetyltransferase activities and are phenotypically classified as rapid or slow acetylators. Mice have a similar genetic polymorphism in N-acetyltransferase activity and have been used as models of the human polymorphism in many...

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PMID: 1513324

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Cloned mouse N-acetyltransferases: enzymatic properties of expressed Nat-1 and Nat-2 gene products.PMID 1513324Read ↗

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Molecular mechanism of slow acetylation of drugs and carcinogens in humans.Semantic proximity Read ↗

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Catalytic properties and heat stabilities of novel recombinant human N-acetyltransferase 2 allozymes support existence of genetic heterogeneity within the slow acetylator phenotype.Semantic proximity Read ↗

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