Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification and functional characterization of novel polymorphisms associated with the genes for arylamine N-acetyltransferases in mice.

Pharmacogenetics - 1 Jul 2002

Boukouvala Sotiria, Price Naomi, Sim Edith

Abstract excerpt

Arylamine N-acetyltransferase (NAT) polymorphism in humans has been associated with variation in susceptibility to drug toxicity and cancer. In mice, three NAT isoenzymes are encoded by Nat1, Nat2 and Nat3 genes. Only Nat2 has been shown previously to be polymorphic, a single nucleotide substitution causing the slow acetylator phenotype in the A/J strain. We sequenced the Nat genes from inbred (CBA and 129/Ola),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arylamine N-Acetyltransferase
Share to Disease Susceptibility

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Primers

Share to Isoenzymes

Share to Mice, Inbred CBA

Share to Mice, Inbred Strains

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 12142728
DOI: 10.1097/00008571-200207000-00006

Genes

NAT2
NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification and functional characterization of novel polymorphisms associated with the genes for arylamine N-acetyltransferases in mice.PMID 12142728Read ↗

Polymorphism of human acetyltransferases.Semantic proximity Read ↗

Tissue expression and genomic sequences of rat N-acetyltransferases rNat1, rNat2, rNat3, and Functional characterization of a novel rNat3*2 genetic variant.Semantic proximity Read ↗

A method for genotyping murine arylamine N-acetyltransferase type 2 (NAT2): a gene expressed in preimplantation embryonic stem cells encoding an enzyme acetylating the folate catabolite p-aminobenzoylglutamate.Semantic proximity Read ↗

ArylamineN-acetyltransferasesSemantic proximity Read ↗

Cloned mouse N-acetyltransferases: enzymatic properties of expressed Nat-1 and Nat-2 gene products.Semantic proximity Read ↗

Polymorphisms of N-acetyltransferase genes.Semantic proximity Read ↗

Pharmacogenetics of the arylamine N-acetyltransferases.Semantic proximity Read ↗

Tissue- and gender-specific expression of N-acetyltransferase 2 (Nat2*) during development of the outbred mouse strain CD-1.Semantic proximity Read ↗

Slow acetylation in mice is caused by a labile and catalytically impaired mutant N-acetyltransferase (NAT2 9).Semantic proximity Read ↗

Generation and functional characterization of arylamine N-acetyltransferase Nat1/Nat2 double-knockout mice.Semantic proximity Read ↗

Arylamine N-acetyltransferases: From Structure to FunctionSemantic proximity Read ↗

Diverse point mutations in the human gene for polymorphic N-acetyltransferase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.