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Article

Generation and functional characterization of arylamine N-acetyltransferase Nat1/Nat2 double-knockout mice.

Molecular pharmacology - 1 Jul 2003

Sugamori Kim S, Wong Sharon, Gaedigk Andrea, Yu Violeta, Abramovici Hanan, Rozmahel Richard, Grant Denis M

Abstract excerpt

Arylamine N-acetyltransferases (NATs) catalyze the biotransformation of a variety of arylamine drugs and carcinogens and may play diametrically opposing roles in enhancing either the detoxification of these chemicals or their metabolic activation into DNA-binding electrophiles. To facilitate the study of these processes, we have generated a Nat1/Nat2 double-knockout mouse model by gene targeting in embryonic stem...

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Source

Identifiers

PMID: 12815173
DOI: 10.1124/mol.64.1.170

Genes

NAT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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