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Article

Systemic functional expression of N-acetyltransferase polymorphism in the F344 Nat2 congenic rat.

Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2008

Hein David W, Bendaly Jean, Neale Jason R, Doll Mark A

Abstract excerpt

Rat lines congenic for the rat N-acetyltransferase 2 [(RAT)Nat2] gene were constructed and characterized. F344 (homozygous Nat2 rapid) males were mated to Wistar Kyoto (homozygous Nat2 slow) females to produce heterozygous F1. F1 females were then backcrossed to F344 males. Heterozygous acetylator female progeny from this and each successive backcross were identified by rat Nat2 genotyping and mated with F344...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Arylamine N-Acetyltransferase

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Source

Open in PubMed Open full text

Identifiers

PMID: 18799801
DOI: 10.1124/dmd.108.023960
PMCID: PMC2596689

Genes

NAT2
NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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