Article
Polymorphisms of N-acetyltransferase genes.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Jan 2000
Grant D M, Blum M, Meyer U A
Abstract excerpt
1. A genetic polymorphism of human liver arylamine N-acetyltransferase (NAT) enzyme activity leads to wide variation in the disposition of many drugs and potential carcinogens, resulting in differential susceptibility to chemical-induced toxicity. 2. During studies to determine the biochemical and molecular mechanisms underlying this pharmacogenetic defect, we cloned two human genes, NAT1 and NAT2, which encode...
Topics
- Acetylation
- Acetyltransferases
- DNA Probes
- Humans
- Liver
- Phenotype
- Polymerase Chain Reaction
- Polymorphism, Genetic