Molecular mechanism of slow acetylation of drugs and carcinogens in humans.

doi:10.1073/pnas.88.12.5237

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Article

Molecular mechanism of slow acetylation of drugs and carcinogens in humans.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 1991

Blum M, Demierre A, Grant D M, Heim M, Meyer U A

Abstract excerpt

The acetylation polymorphism is one of the most common genetic variations in the transformation of drugs and chemicals. More than 50% of individuals in Caucasian populations are homozygous for a recessive trait and are of the "slow acetylator" phenotype. They are less efficient than "rapid acetylators" in the metabolism of numerous drugs and environmental and industrial chemicals. The acetylation polymorphism is...

Topics

Acetylation
Acetyltransferases
Alleles
Base Sequence
Blotting, Northern
Blotting, Western
Carcinogens
Homozygote
Humans
Isoenzymes
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nucleic Acids

Pharmaceutical Preparations

Phenotype

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Source

Open in PubMed Open full text

Identifiers

PMID: 1675794
DOI: 10.1073/pnas.88.12.5237
PMCID: PMC51847

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1675794-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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