Article
Catalytic properties and heat stabilities of novel recombinant human N-acetyltransferase 2 allozymes support existence of genetic heterogeneity within the slow acetylator phenotype.
Archives of toxicology - 1 Aug 2017
Hein David W, Doll Mark A
Abstract excerpt
Human N-acetyltransferase 2 (NAT2) catalyzes the N-acetylation of numerous aromatic amine drugs such as sulfamethazine (SMZ) and hydrazine drugs such as isoniazid (INH). NAT2 also catalyzes the N-acetylation of aromatic amine carcinogens such as 2-aminofluorene and the O- and N,O-acetylation of aromatic amine and heterocyclic amine metabolites. Genetic polymorphism in NAT2 modifies drug efficacy and toxicity as...
Topics
- Acetylation
- Arylamine N-Acetyltransferase
- Carcinogens
- Catalysis
- Genetic Heterogeneity
- Hot Temperature
- Humans
- Isoenzymes
- Isoniazid
- Phenotype
- Polymorphism, Genetic
- Recombinant Proteins
- Sulfamethazine