Human Arylamine <i>N</i> -Acetyltransferase Genes: Isolation, Chromosomal Localization, and Functional Expression

Abstract excerpt

N-Acetylation by hepatic arylamine N-acetyltransferase (NAT, EC 2.3.1.5) is a major route in the metabolism and detoxification of numerous drugs and foreign chemicals. NAT is the target of a common genetic polymorphism of clinical relevance in human populations. We have used our recently isolated rabbit cDNA rnat to clone three human NAT genes from human leukocyte DNA. None of the three genomic coding sequences...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Epigenetics and DNA Methylation
• Share to Pancreatic function and diabetes
• Share to Polyamine Metabolism and Applications