Article
Recombinant expression and catalytic analysis of rapid and slow acetylator Syrian hamster chimeric NAT2 alleles.
Archives of toxicology - 1 Jan 1997
Hein D W, Ferguson R J, Doll M A, Deitz A C
Abstract excerpt
Polymorphic aromatic amine N-acetyltransferase (NAT2) catalyzes the N-acetylation of aromatic amines and the metabolic activation of N-hydroxyarylamines (via O-acetylation) and N-hydroxy-N-acetylarylamines (via N,O-acetylation) to electrophilic intermediates that mutate DNA. Acetylation capacity...
Topics
- Acetylation
- Alleles
- Animals
- Arylamine N-Acetyltransferase
- Blotting, Western
- Chimera
- Cloning, Molecular
- Cricetinae
- Gene Expression Regulation
- In Vitro Techniques
- Mesocricetus
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Recombination, Genetic