Article
Cloning, expression, and functional characterization of two mutant (NAT2(191) and NAT2(341/803)) and wild-type human polymorphic N-acetyltransferase (NAT2) alleles.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000
Ferguson R J, Doll M A, Rustan T D, Gray K, Hein D W
Abstract excerpt
The N-acetylation polymorphism segregates individuals into rapid, intermediate, and slow acetylator phenotypes via monogenic inheritance at the NAT2 locus. In a previous study (Arch. Toxicol. 67, 445-452, 1993), we uncovered discrepancies between apparent NAT2 acetylator genotype based on polymer...
Topics
- Acetylation
- Alleles
- Arylamine N-Acetyltransferase
- Base Sequence
- Biotransformation
- Blotting, Western
- Carcinogens
- Cloning, Molecular
- Enzyme Stability
- Escherichia coli
- Fluorenes
- Gene Expression
- Humans
- Isoenzymes
- Kinetics
- Molecular Sequence Data
- Point Mutation
- Polymerase Chain Reaction