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Article

The Fen1 extrahelical 3'-flap pocket is conserved from archaea to human and regulates DNA substrate specificity.

Nucleic acids research - 1 Jan 2004

Friedrich-Heineken Erica, Hübscher Ulrich

Abstract excerpt

Fen1 is a key enzyme for the maintenance of genetic stability in archaea and eukaryotes and is classified as a tumor suppressor. Very recent structural data obtained from Archaeoglobus fulgidus Fen1 suggest that an extrahelical 3'-flap pocket is responsible for substrate specificity, by binding to the unpaired 3'-flap and by opening and kinking the DNA. Since the extrahelical 3'-flap pocket in archaeal Fen1...

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Identifiers

PMID: 15131255
DOI: 10.1093/nar/gkh576
PMCID: PMC419464

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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