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Article

Interaction interface of human flap endonuclease-1 with its DNA substrates.

The Journal of biological chemistry - 4 Jun 2004

Qiu Junzhuan, Liu Ren, Chapados Brian R, Sherman Mark, Tainer John A, Shen Binghui

Abstract excerpt

Flap endonuclease-1 or FEN-1 is a structure-specific and multifunctional nuclease critical for DNA replication, repair, and recombination; however, its interaction with DNA substrates has not been fully understood. In the current study, we have defined the borders of the interaction between the FEN-1 protein and its DNA substrates and identified six clusters of conserved positively charged amino acid residues,...

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Source

Identifiers

PMID: 15037610
DOI: 10.1074/jbc.M401464200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interaction interface of human flap endonuclease-1 with its DNA substrates.PMID 15037610Read ↗

Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways.Semantic proximity Read ↗

The DNA-protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations.Semantic proximity Read ↗

The Fen1 extrahelical 3'-flap pocket is conserved from archaea to human and regulates DNA substrate specificity.Semantic proximity Read ↗

Observation of unpaired substrate DNA in the flap endonuclease-1 active site.Semantic proximity Read ↗

Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases.Semantic proximity Read ↗

Human Fanconi anemia complementation group a protein stimulates the 5' flap endonuclease activity of FEN1.Semantic proximity Read ↗

A conserved loop-wedge motif moderates reaction site search and recognition by FEN1.Semantic proximity Read ↗

Processing of branched DNA intermediates by a complex of human FEN-1 and PCNASemantic proximity Read ↗

The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair.Semantic proximity Read ↗

Cleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrate.Semantic proximity Read ↗

Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair.Semantic proximity Read ↗

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