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Article

Human Fanconi anemia complementation group a protein stimulates the 5' flap endonuclease activity of FEN1.

PloS one - 1 Jan 2013

Qian Liangyue, Yuan Fenghua, Rodriguez-Tello Paola, Padgaonkar Suyog, Zhang Yanbin

Abstract excerpt

In eukaryotic cells, Flap endonuclease 1 (FEN1) is a major structure-specific endonuclease that processes 5' flapped structures during maturation of lagging strand DNA synthesis, long patch base excision repair, and rescue of stalled replication forks. Here we report that fanconi anemia complementation group A protein (FANCA), a protein that recognizes 5' flap structures and is involved in DNA repair and...

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Source

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Identifiers

PMID: 24349332
DOI: 10.1371/journal.pone.0082666
PMCID: PMC3857783

Genes

FEN1
FANCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Human Fanconi anemia complementation group a protein stimulates the 5' flap endonuclease activity of FEN1.PMID 24349332Read ↗

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