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Article

Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function.

Neoplasia (New York, N.Y.) - 1 Jun 2012

Jaiswal Aruna S, Armas Melissa L, Izumi Tadahide, Strauss Phyllis R, Narayan Satya

Abstract excerpt

In previous studies, we found that adenomatous polyposis coli (APC) blocks the base excision repair (BER) pathway by interacting with 5'-flap endonuclease 1 (Fen1). In this study, we identify the molecular features that contribute to the formation and/or stabilization of the APC/Fen1 complex that determines the extent of BER inhibition, and the subsequent accumulation of DNA damage creates mutagenic lesions...

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Source

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Identifiers

PMID: 22787431
DOI: 10.1593/neo.12680
PMCID: PMC3394192

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function.PMID 22787431Read ↗

The FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation.Semantic proximity Read ↗

Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression.Semantic proximity Read ↗

Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways.Semantic proximity Read ↗

Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair.Semantic proximity Read ↗

Functional FEN1 genetic variants contribute to risk of hepatocellular carcinoma, esophageal cancer, gastric cancer and colorectal cancer.Semantic proximity Read ↗

Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair.Semantic proximity Read ↗

Fen1 mutations result in autoimmunity, chronic inflammation and cancers.Semantic proximity Read ↗

Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases.Semantic proximity Read ↗

The Fen1 extrahelical 3'-flap pocket is conserved from archaea to human and regulates DNA substrate specificity.Semantic proximity Read ↗

Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice.Semantic proximity Read ↗

Human Fanconi anemia complementation group a protein stimulates the 5' flap endonuclease activity of FEN1.Semantic proximity Read ↗

Molecular mechanism of adenomatous polyposis coli-induced blockade of base excision repair pathway in colorectal carcinogenesis.Semantic proximity Read ↗

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