Article
The FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation.
Oncogene - 12 Jan 2017
Sun H, He L, Wu H, Pan F, Wu X, Zhao J, Hu Z, Sekhar C, Li H, Zheng L, Chen H, Shen B H, Guo Z
Abstract excerpt
Flap endonuclease-1 (FEN1) is a multifunctional, structure-specific nuclease that has a critical role in maintaining human genome stability. FEN1 mutations have been detected in human cancer specimens and have been suggested to cause genomic instability and cancer predisposition. However, the exact relationship between FEN1 deficiency and cancer susceptibility remains unclear. In the current work, we report a...
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