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Article

Observation of unpaired substrate DNA in the flap endonuclease-1 active site.

Nucleic acids research - 1 Nov 2013

Finger L David, Patel Nikesh, Beddows Amanda, Ma Long, Exell Jack C, Jardine Emma, Jones Anita C, Grasby Jane A

Abstract excerpt

The structure- and strand-specific phosphodiesterase flap endonuclease-1 (FEN1), the prototypical 5'-nuclease, catalyzes the essential removal of 5'-single-stranded flaps during replication and repair. FEN1 achieves this by selectively catalyzing hydrolysis one nucleotide into the duplex region o...

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Identifiers

PMID: 23975198
DOI: 10.1093/nar/gkt737
PMCID: PMC3834815

Genes

FEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23975198-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Observation of unpaired substrate DNA in the flap endonuclease-1 active site.PMID 23975198Read ↗

Interaction interface of human flap endonuclease-1 with its DNA substrates.Semantic proximity Read ↗

A conserved loop-wedge motif moderates reaction site search and recognition by FEN1.Semantic proximity Read ↗

The DNA-protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations.Semantic proximity Read ↗

Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases.Semantic proximity Read ↗

Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways.Semantic proximity Read ↗

Human Fanconi anemia complementation group a protein stimulates the 5' flap endonuclease activity of FEN1.Semantic proximity Read ↗

Processing of branched DNA intermediates by a complex of human FEN-1 and PCNASemantic proximity Read ↗

The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair.Semantic proximity Read ↗

Cleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrate.Semantic proximity Read ↗

Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.Semantic proximity Read ↗

Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair.Semantic proximity Read ↗

The Fen1 extrahelical 3'-flap pocket is conserved from archaea to human and regulates DNA substrate specificity.Semantic proximity Read ↗

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