Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells

doi:10.1093/nar/gkh570

Article

Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells

28 Apr 2004

Abstract excerpt

Growth factor independence-1 (GFI1) and GFI1B are closely related, yet differentially expressed transcriptional repressors with nearly identical DNA binding domains. GFI1 is upregulated in the earliest thymocyte precursors, while GFI1B expression is restricted to T lymphopoiesis stages coincident with activation. Transgenic expression of GFI1 potentiates T-cell activation, while forced GFI1B expression decreases...

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